If you've been researching GLP-1 medications for weight loss or diabetes, you've likely encountered both "semaglutide" and "Ozempic." Are they the same thing? The short answer is yes and no—and understanding the distinction is important when considering your treatment options.
The Short Answer
Semaglutide is the active pharmaceutical ingredient (API)—the actual drug molecule. Ozempic is a brand name for semaglutide made by Novo Nordisk. Think of it like how "ibuprofen" is the drug and "Advil" is a brand name for ibuprofen.
Understanding Semaglutide Brand Names
Novo Nordisk, the pharmaceutical company that developed semaglutide, sells it under different brand names depending on the use and formulation:
| Brand Name | FDA Approved For | Formulation | Max Dose |
|---|---|---|---|
| Ozempic | Type 2 Diabetes | Injectable pen | 2 mg/week |
| Wegovy | Weight Loss (Obesity) | Injectable pen | 2.4 mg/week |
| Rybelsus | Type 2 Diabetes | Oral tablet | 14 mg/day |
All three contain the same active ingredient (semaglutide), but they're formulated and dosed differently. Wegovy is specifically approved for chronic weight management and goes to a higher dose than Ozempic, which is why it typically produces more weight loss.
What About Compounded Semaglutide?
You've probably also heard about "compounded semaglutide." This is semaglutide that's prepared by compounding pharmacies rather than manufactured by Novo Nordisk. Here's how it differs:
- Made by Novo Nordisk
- FDA-approved product
- Pre-filled pen devices
- May be covered by insurance
- $900-$1,700/month without insurance
- Made by compounding pharmacies
- Same active ingredient
- Vials with syringes (usually)
- Not covered by insurance
- $99-$399/month typically
Why Can Pharmacies Compound Semaglutide?
The FDA allows compounding pharmacies to create medications when there's a documented drug shortage. Ozempic and Wegovy have been on the FDA's drug shortage list since 2022, which permits 503A and 503B compounding pharmacies to legally prepare semaglutide. When/if the shortage ends, compounded versions may no longer be available.
Is Compounded Semaglutide as Effective as Ozempic?
When compounded properly by a reputable 503B pharmacy, compounded semaglutide contains the same active molecule and should work identically. Many patients report similar results to brand-name versions. However, there are some considerations:
Quality Varies by Pharmacy
Not all compounding pharmacies are equal. 503B pharmacies are FDA-registered and must follow strict quality standards, while 503A pharmacies have less oversight. Always verify that your provider uses a reputable 503B pharmacy.
Formulation Differences
Compounded semaglutide is often formulated with additional ingredients like B12 (cyanocobalamin) for stability or potential added benefits. The base semaglutide molecule is the same, but the overall formulation may differ slightly.
Delivery Method
Brand-name Ozempic and Wegovy come in pre-filled pens that are very easy to use. Compounded semaglutide typically comes in vials requiring you to draw up the dose with a syringe, which some people find less convenient.
How to Choose Between Brand-Name and Compounded
The decision often comes down to cost and insurance coverage:
Choose Brand-Name If:
- • Your insurance covers Ozempic or Wegovy
- • You prefer the convenience of pre-filled pens
- • You want an FDA-approved product specifically
- • Cost is not a major concern
Choose Compounded If:
- • You don't have insurance coverage for brand-name
- • Cost is a significant factor ($99-399 vs $900-1700/month)
- • You're comfortable with vial and syringe administration
- • You're using a provider with a reputable 503B pharmacy
Finding a Provider for Semaglutide
Whether you choose brand-name or compounded semaglutide, you'll need a prescription from a licensed healthcare provider. Many telehealth companies now specialize in GLP-1 medications and make the process convenient.
Check out our comprehensive provider reviews to compare options. Our top-rated provider, CoreAge Rx, offers compounded semaglutide starting at $99/month from FDA-registered 503B pharmacies.
Frequently Asked Questions
Can I switch from Ozempic to compounded semaglutide?
Yes, many people switch to save money. Your new provider will help you transition at an equivalent dose. The active ingredient is the same, so there shouldn't be any difference in how you feel.
Is compounded semaglutide legal?
Yes, when there's an FDA-recognized drug shortage (which currently exists for semaglutide), compounding pharmacies can legally prepare the medication. This has been the case since 2022.
Will compounded semaglutide always be available?
Not necessarily. If Novo Nordisk resolves the shortage, compounded semaglutide may no longer be legally available. However, as of 2026, the shortage continues and compounded versions remain an option.
The Bottom Line
Semaglutide is the drug; Ozempic is a brand name. Both brand-name (Ozempic, Wegovy) and compounded semaglutide contain the same active ingredient. The main differences are cost, delivery method, and regulatory status. For most people paying out of pocket, compounded semaglutide from a reputable provider offers the same benefits at a fraction of the cost.