Tirzepatide costs more than semaglutide almost everywhere, and the gap widens as you titrate. That makes one question more important here than anywhere else in GLP-1 shopping: does your provider charge the same at 15 mg as at 2.5 mg, or does the price climb with every step?
The Titration Trap
VITAstir publishes its full price ladder honestly, and it shows the problem clearly: $145 at 2.5 mg, $299 at 5 mg, $399 at 7.5 mg, $449 at 10 mg, $499 at 12.5 mg and $599 at 15 mg. A patient reaching a maintenance dose pays four times the entry price. Providers that hold one flat rate can end up considerably cheaper despite a higher advertised starting price.
Best Compounded Tirzepatide Providers
One rate covers the entire 2 mg to 15 mg range, which makes it the clear pick for anyone expecting to titrate upward. It also names its compounding pharmacy and medical director.
- $199 first month, then $249.99 a month flat
- Covers all doses from 2 mg to 15 mg
- Names Rush Pharmacy as its 503A partner
- All 50 states, no lock-in
Our top-rated provider, pairing competitive compounded tirzepatide pricing with 503B pharmacy sourcing and a full support package.
- 503B outsourcing facility sourcing
- 2 to 3 day shipping
- Support package included
- Competitive pricing across doses
The lowest published tirzepatide entry price we found, with only two dose tiers rather than a six-step ladder, and no subscription required.
- $133 a month starter tier, $399 for 3 months
- $183 a month high-dose tier
- No membership or subscription
- Pay only if approved
Holds tirzepatide pricing flat at every dose, names five pharmacy partners across 503A and 503B facilities, and publishes a money-back guarantee.
- From $149 to $169 a month by plan length
- Same price at every dose
- Names its pharmacy partners
- HSA, FSA and financing accepted
Compounded tirzepatide in all 50 states plus DC, with medication, physician care, shipping and supplies in one published price.
- $199 for one month, $163 a month on 3 months
- All 50 states plus DC
- Supplies and shipping included
- No membership fees
Compounded tirzepatide with Quest lab work, unlimited clinician visits, group coaching and dietitian support included, plus a formal microdose option.
- From $198 a month on an annual plan
- $359 a month month-to-month
- Labs through Quest included
- Microdose tirzepatide offered
Best Brand-Name Tirzepatide Routes
| Route | Published Price | Notes |
|---|---|---|
| LillyDirect at 2.5 mg | $299 per month | KwikPen for single-patient use, or four vials |
| LillyDirect at 5 mg | $399 per month | Single-patient-use KwikPen |
| LillyDirect at 7.5 mg to 15 mg | $699 per month | Higher strengths, where compounded options are far cheaper |
| Heally | From $299 per month | Brand-name Zepbound or Mounjaro self-pay, free consultation |
| Commercial savings card | As little as $25 | For eligible commercially insured patients, with published caps |
Zepbound is FDA-approved for chronic weight management and for obstructive sleep apnea in adults with obesity. Mounjaro is approved for type 2 diabetes.
Doing the Maths Properly
Compare providers at the dose you expect to maintain on, not the dose you start at. A patient maintaining at 10 mg would pay $449 a month at VITAstir, $249.99 at Precision Telemed, and $699 through LillyDirect. The provider with the lowest advertised entry price is frequently not the cheapest over a year of treatment.
Also account for what is bundled. Freedom Weight Loss Clinic includes follow-up visits, shipping, supplies and taxes in its $185 to $275 per four weeks. Shapely charges membership separately from its $166 a month tirzepatide. Our GLP-1 cost guide walks through building a real annual figure.
Microdosing and Oral Tirzepatide
Two variations are worth knowing about. Microdosing, using lower-than-standard doses, is offered formally by Precision Telemed at $179.99 a month for the 2 mg maintenance plan, by Fridays , and by Midi Health from $34 per weekly dose. Oral tirzepatide is offered by WellMedr , by Fitish RX at $339 a month, by PlexusDx from $279, and by Shed . PlexusDx also runs a dedicated microdose protocol at $129 a month and Fitish a fixed-dose microdose lane at $179. Our GLP-1 microdosing guide covers what the evidence does and does not support. Neither variation is a substitute for a clinical conversation about whether they suit you.
Newer Tirzepatide Options
Ondra Health publishes compounded tirzepatide from $142 a month on an annual plan and $219 month-to-month, with a choice of named pharmacy. Cora Health runs $135 to $225 across its terms with both pharmacies named. SkinnyVIP takes the opposite approach entirely, selling a $695 three-month plan at any dose with no subscription and a full refund if a clinician does not prescribe.
At the other end, Aspire Health publishes a full dose ladder from $149 a vial at 2.5 mg to $299 at 15 mg, which is honest and also a doubling of cost across a normal titration. Our flat-rate pricing comparison works through why that matters more than the entry price.
Questions to Ask Before Enrolling
- What will I pay at 10 mg and 15 mg, not just at 2.5 mg?
- Is the price flat across doses, or does it step up at each titration?
- Which pharmacy compounds this, and is it 503A or 503B?
- Are supplies, shipping and follow-up visits included or extra?
- What happens to prepaid months if I stop treatment early?
- Is tirzepatide the right choice for me clinically, or would semaglutide be? See our full comparison
Frequently Asked Questions
Why is tirzepatide more expensive than semaglutide?
Tirzepatide acts on both GLP-1 and GIP receptors and is priced higher by manufacturers and compounders alike. At nearly every provider we reviewed, tirzepatide costs roughly 40 to 80 percent more than semaglutide, with Fifty 410 being an unusual exception where the reverse is true.
What is the cheapest tirzepatide?
Fifty 410 publishes the lowest entry price at $133 a month for its starter tier. For patients titrating to higher doses, Precision Telemed's flat $249.99 across all doses often works out cheaper over a year than lower entry prices that escalate.
Is compounded tirzepatide the same as Zepbound?
No. Zepbound is the FDA-approved tirzepatide product from Eli Lilly. Compounded tirzepatide is prepared by a compounding pharmacy and is not FDA-approved or evaluated for safety and effectiveness. VITAstir states plainly that its product is not intended to replace the Lilly product.
Can I get Zepbound without insurance?
Yes. LillyDirect sells Zepbound on a self-pay basis, published at $299 a month at 2.5 mg, $399 at 5 mg and $699 at 7.5 mg through 15 mg. Heally also offers brand-name Zepbound from $299 a month self-pay.
What is the difference between Zepbound and Mounjaro?
Both are tirzepatide from Eli Lilly. Zepbound is FDA-approved for chronic weight management and for obstructive sleep apnea in adults with obesity; Mounjaro is approved for type 2 diabetes. Providers such as Heally require a type 2 diabetes diagnosis for Mounjaro specifically.
Does tirzepatide need refrigeration?
Brand-name tirzepatide requires refrigeration, which is why providers ship it in temperature-controlled packaging. Compounded formulations vary, and VITAstir states its product does not need refrigeration during shipping. Always follow the storage instructions supplied with your medication; our storage and shipping guide covers this in detail.
Medical Disclaimer
This article is general information, not medical advice. GLP-1 medications are prescription drugs with real risks and contraindications, and only a licensed clinician who knows your history can decide whether one is appropriate for you. Prices, programs and policies described here reflect what providers published at the time of writing and change frequently; verify everything directly before enrolling. Read our full medical disclaimer.
Last reviewed: August 24, 2026