GLP-1 receptor agonists require careful dose titration to minimize side effects while achieving optimal results. This comprehensive guide covers the dosing schedules for all major GLP-1 medications used for weight loss and diabetes management.
Why Titration Matters
All GLP-1 medications start at a low dose and gradually increase over weeks or months. This "titration" process helps your body adjust to the medication, significantly reducing nausea and other GI side effects that can occur if you start at a higher dose.
Quick Comparison: All GLP-1 Medications
| Medication | Active Ingredient | Starting Dose | Maximum Dose | Time to Max |
|---|---|---|---|---|
| Ozempic | Semaglutide | 0.25 mg/week | 2 mg/week | 16+ weeks |
| Wegovy | Semaglutide | 0.25 mg/week | 2.4 mg/week | 16-20 weeks |
| Mounjaro | Tirzepatide | 2.5 mg/week | 15 mg/week | 20+ weeks |
| Zepbound | Tirzepatide | 2.5 mg/week | 15 mg/week | 20+ weeks |
Semaglutide Dosing (Ozempic & Wegovy)
Semaglutide-based medications follow similar titration schedules, though Wegovy reaches a higher maximum dose since it's specifically approved for weight loss.
| Weeks | Dose | Purpose |
|---|---|---|
| Weeks 1-4 | 0.25 mg | Initial adjustment period |
| Weeks 5-8 | 0.5 mg | First therapeutic dose |
| Weeks 9-12 | 1 mg | Standard maintenance (Ozempic max for diabetes) |
| Weeks 13-16 | 1.7 mg | Enhanced weight loss (Wegovy) |
| Week 17+ | 2.4 mg | Maximum dose (Wegovy only) |
For detailed information on each medication, see our specific guides:
Tirzepatide Dosing (Mounjaro & Zepbound)
Tirzepatide is a dual GIP/GLP-1 agonist that typically produces greater weight loss than semaglutide. The dosing schedule is identical for both Mounjaro (diabetes) and Zepbound (weight loss).
| Weeks | Dose | Purpose |
|---|---|---|
| Weeks 1-4 | 2.5 mg | Initial adjustment period |
| Weeks 5-8 | 5 mg | First therapeutic dose |
| Weeks 9-12 | 7.5 mg | Intermediate dose |
| Weeks 13-16 | 10 mg | Higher therapeutic dose |
| Weeks 17-20 | 12.5 mg | Advanced dose |
| Week 21+ | 15 mg | Maximum dose |
For detailed information on each medication, see our specific guides:
Key Titration Principles
- • Stay at each dose for the full 4 weeks
- • Inject on the same day each week
- • Stay hydrated throughout treatment
- • Eat smaller, more frequent meals
- • Contact your provider if side effects are severe
- • Skip doses to "save up" medication
- • Increase dose faster than recommended
- • Double up if you miss a dose
- • Stop suddenly without medical guidance
- • Ignore persistent vomiting or severe pain
When to Stay at a Lower Dose
Not everyone needs to reach the maximum dose. You may stay at a lower dose if:
- You're achieving your goals: If you're losing weight steadily and feeling good, there's no need to increase.
- Side effects are manageable: If higher doses cause intolerable side effects, a lower dose may be your sweet spot.
- Your provider recommends it: Based on your health profile, your doctor may suggest a maintenance dose below the maximum.
Compounded Semaglutide & Tirzepatide Dosing
Compounded versions of these medications follow the same titration principles but may offer more flexible dosing options. Your telehealth provider will customize your schedule based on your response to treatment.
Important Note
Compounded medications are measured in mg/mL concentrations. Your provider will calculate the correct injection volume based on the concentration of your specific prescription. Always follow your provider's dosing instructions exactly.
Find a Provider
Ready to start your GLP-1 journey? Browse our provider reviews to find a telehealth service that fits your needs and budget. Many providers offer both brand-name and compounded options with personalized dosing support.
The Bottom Line
Proper dose titration is essential for GLP-1 treatment success. Starting low and increasing gradually minimizes side effects while allowing your body to adjust. Whether you're on semaglutide or tirzepatide, patience during the titration phase leads to better long-term outcomes.