Zepbound (tirzepatide) is FDA-approved for chronic weight management and has shown impressive results in clinical trials. This guide covers the complete dosing schedule, what to expect at each level, and how to optimize your treatment.
About Zepbound
Zepbound contains tirzepatide, a dual GIP/GLP-1 receptor agonist. It's the same active ingredient as Mounjaro but is specifically approved for weight loss in adults with obesity (BMI ≥30) or overweight (BMI ≥27) with at least one weight-related condition.
Zepbound Dosage Chart
| Phase | Weeks | Dose | Pen Color | Expected Weight Loss |
|---|---|---|---|---|
| Starting | 1-4 | 2.5 mg | Purple | 1-3% |
| Titration | 5-8 | 5 mg | Purple | 3-6% |
| Titration | 9-12 | 7.5 mg | Gray | 6-10% |
| Titration | 13-16 | 10 mg | Teal | 10-14% |
| Titration | 17-20 | 12.5 mg | Red | 14-18% |
| Maximum | 21+ | 15 mg | Blue | 18-25%+ |
* Weight loss percentages are approximate and based on clinical trial data. Individual results vary significantly based on diet, exercise, and metabolic factors.
What to Expect at Each Dose
The starting dose is primarily for your body to adjust. You may notice:
- • Mild appetite suppression
- • Possible nausea (usually mild)
- • Early satiety when eating
- • Minimal weight loss (1-3 lbs typical)
The first therapeutic dose where most people start seeing real results:
- • Noticeable appetite reduction
- • Food noise begins to quiet
- • More consistent weight loss begins
- • Side effects may temporarily increase then improve
An intermediate dose that works well as a maintenance level for many:
- • Strong appetite suppression
- • Steady weight loss of 1-2 lbs/week
- • Improved blood sugar control
- • Many find this dose sufficient for their goals
A higher therapeutic dose for enhanced results:
- • Significant appetite control
- • Continued steady weight loss
- • Most GI side effects have resolved
- • Popular maintenance dose for many patients
An advanced dose for those needing additional effect:
- • Very strong appetite suppression
- • May need to consciously ensure adequate nutrition
- • Breaking through weight loss plateaus
- • Close to maximum therapeutic effect
The maximum approved dose:
- • Maximum appetite suppression
- • Best results for those who need it
- • Not everyone needs to reach this dose
- • Clinical trials showed up to 25% weight loss at this level
Zepbound Pen Strengths
Zepbound comes in single-dose pens. Each pen contains one dose, and you use one pen per week:
| Dose | Pens per Box | Supply |
|---|---|---|
| 2.5 mg | 4 pens | 4 weeks |
| 5 mg | 4 pens | 4 weeks |
| 7.5 mg | 4 pens | 4 weeks |
| 10 mg | 4 pens | 4 weeks |
| 12.5 mg | 4 pens | 4 weeks |
| 15 mg | 4 pens | 4 weeks |
Managing Side Effects During Titration
Common Side Effects
- • Nausea (most common, usually temporary)
- • Diarrhea or constipation
- • Decreased appetite
- • Injection site reactions
- • Fatigue
Management Tips
- • Eat smaller, more frequent meals
- • Avoid fatty, greasy, or spicy foods
- • Stay well hydrated
- • Take walks after meals
- • Use ginger for nausea relief
When to Contact Your Doctor
Seek medical attention if you experience severe abdominal pain, persistent vomiting, signs of pancreatitis, or symptoms of an allergic reaction (rash, difficulty breathing, swelling).
Frequently Asked Questions
Do I have to reach 15 mg?
No. Many people achieve excellent results at lower doses like 7.5 mg or 10 mg. The goal is to find the dose that gives you good results with manageable side effects.
What if I can't tolerate a higher dose?
You can stay at a lower dose or even go back down. Your provider can adjust your schedule based on your tolerance. The best dose is the one that works for you.
Can I increase faster than every 4 weeks?
It's not recommended. The 4-week intervals allow your body to adjust and help minimize side effects. Faster titration often leads to more severe GI symptoms.
Getting Zepbound
Zepbound requires a prescription from a licensed healthcare provider. Many telehealth platforms now offer Zepbound or compounded tirzepatide alternatives. Check out our provider reviews to compare your options.
The Bottom Line
Zepbound's titration schedule is designed to maximize results while minimizing side effects. Starting at 2.5 mg and gradually increasing every 4 weeks gives your body time to adjust. Most people find their optimal dose somewhere between 7.5 mg and 15 mg—work with your provider to find what works best for you.