GLP-1 SupplementUpdated: September 2026

Plus+Ultra GLP-1 Review: Says Transparent, Scores Middling

An Amazon-led brand built on a transparent labelling promise, with a gut-focused synbiotic and an appetite formula, holding an independent SuppCo TrustScore of 5.7 out of 10.

3/5

Pros

  • +Explicit commitment to transparent labelling rather than proprietary blends
  • +Two distinct products: an appetite formula and a gut synbiotic
  • +The gut product combines prebiotic, probiotic, postbiotic and enzymes
  • +Average price around $24.49, cheap for the category
  • +Ranks in the top 10 percent of brands by SuppCo user popularity
  • +Amazon availability with no subscription requirement

Cons

  • -An independent TrustScore of 5.7 out of 10 is middling at best
  • -Amazon-native brands are hard to assess for manufacturing standards
  • -No published clinical evidence for either formula
  • -Multi-layered formulation means many ingredients at modest doses
  • -Little independent coverage beyond aggregator listings
  • -Not FDA evaluated, like all dietary supplements
#1 PICK

CoreAge Rx

Editor's Choice

Our #1 recommended provider for GLP-1 medications

$99/mo

12-month plan

503B Pharmacy

FDA registered

Fast Shipping

2-3 business days

5/5 Rating

Top rated

Plus+Ultra is an Amazon-led brand promising transparent labelling across two GLP-1 products, holding an independent SuppCo TrustScore of 5.7 out of 10.

Overview

Plus+Ultra sells supplements principally through Amazon, describing its approach as ultra-concentrated nutritional, mineral and herbal formulations with transparent labelling and multi-layered construction. Two products are relevant here: a GLP-1 Supplement for Weight Management and Appetite Control in a 60-count bottle, and a GLP-1 Companion Gut Supplement, also 60 count, combining digestive enzymes with prebiotic, probiotic, postbiotic and synbiotic components.

The transparent labelling commitment is worth crediting as an intention, since proprietary blends are the default in this category and they make independent assessment impossible. Splitting the range into an appetite product and a gut product is also more coherent than cramming everything into one capsule, which is what several budget competitors do.

The independent picture is where enthusiasm should moderate. SuppCo, an aggregator that scores supplements on certifications, formulation quality and related factors, gives Plus+Ultra a TrustScore of 5.7 out of 10 across nine scored products, with an average price of $24.49. It also notes that the brand ranks in the top 10 percent of most popular brands among SuppCo users. That combination, popular and cheap but middling on quality scoring, is a reasonable summary of what an Amazon-native supplement brand typically offers. There is little independent coverage beyond aggregator listings.

Plus+Ultra GLP-1 at a Glance

DetailWhat Plus+Ultra GLP-1 Publishes
Type of productDietary supplements, capsules and softgels
Product lineGLP-1 Supplement for appetite, and GLP-1 Companion Gut Supplement
Format60 count per bottle
Gut product componentsDigestive enzymes, prebiotic, probiotic, postbiotic and synbiotic
Stated approachTransparent labelling, no proprietary blends
Independent scoreSuppCo TrustScore of 5.7 out of 10
Average price$24.49 across nine scored products
Brand popularityTop 10 percent among SuppCo users
Primary channelAmazon
FDA evaluatedNo, as with all dietary supplements

What Is Actually in It

Formula and Format
  • A GLP-1 supplement aimed at appetite control and weight management
  • A separate GLP-1 Companion Gut Supplement
  • Digestive enzymes with prebiotic, probiotic, postbiotic and synbiotic components
  • A stated commitment to transparent labelling
  • 60 capsules per bottle
  • Low pricing at an average of $24.49 across the range

Supplement or Medication?

Dietary supplements. Neither product contains a GLP-1 receptor agonist. The appetite formula relies on herbal and mineral ingredients, and the gut formula on enzymes and microbiome components, both of which act indirectly at best.

How You Buy It

1

Buy on Amazon

The brand's primary channel, with no subscription required.

2

Choose appetite or gut

The range splits into two distinct products.

3

Read the label

Transparent labelling is the brand's stated proposition; check it delivers.

4

Set expectations from the score

An independent 5.7 out of 10 is middling.

Who It Is Sold To

  • Adults wanting a low-cost Amazon option
  • No consultation or clinical assessment involved
  • Immunocompromised people should discuss live probiotics with a clinician
  • Not appropriate as a substitute for prescribed obesity treatment
  • Speak to a clinician first if you take glucose-lowering medication
  • Consider better-documented brands if evidence matters to you

Clinical Oversight and Evidence

Clinical Oversight

None. This is an Amazon retail supplement with no clinical involvement, and Amazon-native brands are generally harder to assess for manufacturing standards than brands with retail or practitioner distribution.

Evidence

No published clinical evidence for either formula. The independent SuppCo score of 5.7 out of 10 reflects certifications and formulation rather than efficacy, and it is a middling result. There is little independent coverage of the brand beyond aggregator listings.

Availability and Shipping

Where to Buy

Principally Amazon, where both products are listed under the Plus+Ultra brand.

Shipping

Amazon shipping. Shelf-stable capsules and softgels with no special handling requirement.

What You Get

  • A stated transparent labelling policy
  • Two distinct products rather than one combined capsule
  • Low pricing across the range
  • Amazon availability with no subscription
  • An independent aggregator listing with a published score
  • No clinical support, and little independent coverage

Pricing

Cheap by the standards of this category, which is the brand's main argument.

Product or PlanPublished PriceWhat It Covers
Average across the range$24.49As calculated by SuppCo across nine products
GLP-1 SupplementAmazon pricing60 count, appetite and weight management
GLP-1 Companion Gut SupplementAmazon pricing60 count, enzymes and microbiome components
SubscriptionNot requiredAmazon subscribe-and-save optional

Pricing reflects what Plus+Ultra GLP-1 published at the time of review and can change without notice. Confirm current pricing directly with the seller before buying.

Membership Fees

None. Amazon subscribe-and-save is optional and can be cancelled from your account.

Annual Cost

Roughly $294 a year at the $24.49 average, among the cheaper options covered here.

Cancellation and Refund Policy

Cancellation

Amazon subscribe-and-save can be cancelled from your account at any time.

Refunds

Amazon's return policy applies.

Insurance, HSA and FSA

Insurance

Not applicable to a retail supplement.

HSA / FSA

Generally not eligible. Dietary supplements are usually excluded from HSA and FSA spending without a letter of medical necessity from a clinician.

For a fuller explanation of how these accounts work with GLP-1 care, see our GLP-1 insurance, HSA and FSA guide.

Who Plus+Ultra GLP-1 May Be Best For

May Be a Good Fit If
  • You want a cheap Amazon option and low commitment
  • You prefer separate appetite and gut products
  • Transparent labelling matters to you as a principle
  • You are experimenting rather than relying on a specific effect
  • You want to avoid subscriptions entirely
  • You accept a middling independent quality score
Limitations to Weigh
  • An independent TrustScore of 5.7 out of 10 is not strong
  • Amazon-native brands are hard to assess for manufacturing
  • No published clinical evidence for either formula
  • Multi-layered formulation implies modest doses of many ingredients
  • Little independent coverage beyond aggregators
  • Better-documented options exist at similar prices

Alternatives to Consider

DietWorks GLP-1 Companion

Publishes actual doses at $19.99.

NutraBetic GLP-1 Companion

Dihydroberberine and colostrum at $9.98.

Bariatric Fusion GLP-ONE

A specific receptor mechanism at $29.99.

Vitamatic GLP-1 Support

A comparable budget option, also with unpublished doses.

You can also compare the whole field in our best GLP-1 supplements and GLP-1 supplement evidence review roundups.

Frequently Asked Questions

What is the SuppCo TrustScore?

An independent aggregator score based on certifications, formulation quality and related factors. Plus+Ultra scores 5.7 out of 10 across nine products, which is middling.

What products does Plus+Ultra sell for GLP-1?

Two: a GLP-1 Supplement for weight management and appetite control, and a GLP-1 Companion Gut Supplement combining digestive enzymes with prebiotic, probiotic, postbiotic and synbiotic components. Both are 60 count.

Is it transparent about its ingredients?

That is the brand's stated proposition, and it is the right instinct in a category dominated by proprietary blends. Check the actual label against the claim before buying.

How much does it cost?

Around $24.49 on average across the range, which places it among the cheaper options in this category.

Is it a reputable brand?

It ranks in the top 10 percent of brands by SuppCo user popularity, but its quality score is middling and there is little independent coverage beyond aggregator listings. Amazon-native brands are generally harder to assess than those with retail or practitioner distribution.

Where can I buy it?

Principally Amazon, with no subscription requirement.

Is it FDA approved?

No. These are dietary supplements, so they do not require FDA approval before marketing and their claims have not been evaluated by the FDA.

Our Verdict

Plus+Ultra sits in the middle of this category in almost every respect. Its stated proposition is ultra-concentrated nutritional, mineral and herbal supplements with transparent labelling and multi-layered formulations, which is the right instinct given how much of this shelf hides behind proprietary blends. It sells two relevant products: a GLP-1 supplement for weight management and appetite control, and a GLP-1 Companion Gut Supplement combining digestive enzymes with prebiotic, probiotic, postbiotic and synbiotic components. The independent picture is less flattering. SuppCo, which scores supplements on certifications and formulation, gives Plus+Ultra 5.7 out of 10 across nine products, while noting it ranks in the top 10 percent of brands by user popularity. Popular and cheap, then, at an average of $24.49, but not independently well rated.

Disclosure: This review reflects our genuine assessment based on research, user feedback, and our evaluation criteria. Some links on this page may be affiliate links, meaning we may earn a commission if you make a purchase through them at no additional cost to you. This does not influence our editorial opinions or ratings.

Compare more providers?