21st Century GLP-1 Daily Support is a $24.99 capsule containing three ingredients, berberine HCl, turmeric extract and chicory inulin, sold at Walmart and Amazon.
Overview
21st Century is a long-established value vitamin brand with broad supermarket and pharmacy distribution. Its GLP-1 Daily Support is a 60-count vegetarian capsule product priced at $24.99 direct and $26.99 at Walmart, marketed as combining high-quality ingredients to support healthy dieting, exercise and metabolism health.
The ingredient list is short, and that is genuinely to its credit. Berberine HCl is listed for healthy sugar metabolism and cardiovascular support, turmeric extract follows, and chicory inulin is included for digestive and immune health. Compare that with the budget competitors that cram nine actives into two capsules, and the arithmetic here is at least plausible: three ingredients leave room for real amounts in a way nine cannot.
Whether that room was used is impossible to say, because the individual doses are not clearly published. That matters most for berberine, whose clinical literature uses 1,000 to 1,500mg daily. Chicory inulin is a legitimate prebiotic whose colonic fermentation produces short-chain fatty acids that stimulate GLP-1 secretion, which is the same real mechanism the expensive fibre products rely on. Turmeric is the weakest of the three: curcumin has notoriously poor oral bioavailability, and no potentiator such as black pepper extract appears in the listing.
21st Century GLP-1 Daily Support at a Glance
| Detail | What 21st Century GLP-1 Daily Support Publishes |
|---|---|
| Type of product | Dietary supplement, vegetarian capsules |
| Format | 60 vegetarian capsules |
| Price | $24.99 direct, $26.99 at Walmart |
| Active ingredients | Berberine HCl, turmeric extract, chicory inulin |
| Number of actives | Three, unusually restrained for this category |
| Published doses | Individual amounts not clearly stated |
| Berberine research range | 1,000 to 1,500mg daily |
| Inulin mechanism | Fermentation producing short-chain fatty acids |
| Retail availability | Walmart, Amazon and direct |
| FDA evaluated | No, as with all dietary supplements |
What Is Actually in It
- Berberine HCl for sugar metabolism and cardiovascular support
- Turmeric extract
- Chicory inulin as a prebiotic fibre
- 60 vegetarian capsules per bottle
- A three-ingredient formula rather than a long list
- No published individual doses
Supplement or Medication?
A dietary supplement. Berberine acts on glucose metabolism through AMPK activation, and inulin is fermented in the colon producing short-chain fatty acids that stimulate GLP-1 secretion. Neither is a GLP-1 receptor agonist.
How You Buy It
Buy at Walmart or direct
$26.99 at Walmart, $24.99 from 21st Century.
Take as directed
60 vegetarian capsules per bottle.
Introduce the inulin gradually
Chicory inulin causes gas in many people at first.
Ask about the doses
The amounts are not published, which is worth querying.
Who It Is Sold To
- Adults wanting a short-ingredient budget option
- No consultation or clinical assessment involved
- Suitable for vegetarians, as the capsules are vegetarian
- Berberine lowers blood sugar and interacts with some medications
- Not appropriate as a substitute for prescribed obesity treatment
- Speak to a clinician first if you take glucose-lowering medication
Clinical Oversight and Evidence
Clinical Oversight
None. This is a retail supplement with no clinical involvement. Berberine acts on the same liver enzymes that metabolise many common medications, so mention it to a pharmacist.
Evidence
Ingredient-level, and undermined by the missing doses. Berberine has a substantial published literature for glucose metabolism, and inulin has real research on prebiotic fermentation and satiety. Turmeric's oral bioavailability problem is well documented. Without published amounts there is no way to compare this product against any of that research, and no trial exists on the finished formula.
Availability and Shipping
Where to Buy
Walmart, Amazon and direct from 21st Century. Also listed in iHerb's curated GLP-1 category.
Shipping
Standard retail shipping for shelf-stable capsules, with in-store availability at Walmart.
What You Get
- A short, legible ingredient list
- Wide retail distribution including Walmart
- Vegetarian capsules
- Low pricing for the category
- A long-established value brand
- No published doses, and no clinical support
Pricing
Cheap for the category, and cheaper than most products with a comparable ingredient list.
| Product or Plan | Published Price | What It Covers |
|---|---|---|
| GLP-1 Daily Support, 60 capsules | $24.99 | Direct from 21st Century |
| At Walmart | $26.99 | 60 vegetarian capsules |
| Subscription | Not required | Ordinary retail purchase |
| Comparable products | From $19.99 | DietWorks publishes its doses at that price |
Pricing reflects what 21st Century GLP-1 Daily Support published at the time of review and can change without notice. Confirm current pricing directly with the seller before buying.
Membership Fees
None. Ordinary retail stock with no membership or recurring commitment.
Annual Cost
Roughly $300 a year at $24.99 monthly, at the cheaper end of the category.
Cancellation and Refund Policy
Cancellation
Not applicable to a retail purchase.
Refunds
Standard consumer retail terms. Walmart and Amazon purchases follow those retailers' policies.
Insurance, HSA and FSA
Insurance
Not applicable to a retail supplement.
HSA / FSA
Generally not eligible. Dietary supplements are usually excluded from HSA and FSA spending without a letter of medical necessity from a clinician.
For a fuller explanation of how these accounts work with GLP-1 care, see our GLP-1 insurance, HSA and FSA guide.
Who 21st Century GLP-1 Daily Support May Be Best For
- You want a short ingredient list you can actually read
- You want berberine and prebiotic fibre in one capsule
- You are vegetarian
- You shop at Walmart and want no subscription
- You want to spend under $27 a month
- You accept the doses are unpublished
- Individual ingredient amounts are not published
- Berberine's researched dose is hard to fit alongside two other actives
- Turmeric is poorly absorbed without a potentiator
- Chicory inulin causes gas and bloating in many people
- No trial on the finished formula
- Cheaper competitors do publish their doses
Alternatives to Consider
DietWorks GLP-1 Companion
Publishes every dose, at $19.99.
Nutricost Berberine
1,200mg of properly dosed berberine at $17.58 on subscription.
Nature's Fusions Nutri GLP-1 Complex
A similar approach with published amounts.
Vitamatic GLP-1 Support
Cheaper still, but with nine ingredients and no doses.
You can also compare the whole field in our best GLP-1 supplements and GLP-1 supplement evidence review roundups.
Frequently Asked Questions
What is in 21st Century GLP-1 Daily Support?
Three actives: berberine HCl for sugar metabolism and cardiovascular support, turmeric extract, and chicory inulin for digestive and immune health. It comes as 60 vegetarian capsules.
Does it publish its doses?
Not clearly, which is the main shortcoming. That matters most for berberine, whose clinical research uses 1,000 to 1,500mg daily.
Is a three-ingredient formula better?
Structurally, yes. Three actives leave room for meaningful amounts in a way that nine cannot. Whether that room was used here is impossible to confirm without published doses.
Why is turmeric the weak inclusion?
Curcumin has notoriously poor oral bioavailability, and products that take it seriously pair it with a potentiator such as black pepper extract. None is listed here.
Will the inulin upset my stomach?
It can. Chicory inulin is a legitimate prebiotic but among the more gas-producing fibres, so introduce it gradually.
How much does it cost?
$24.99 direct from 21st Century, or $26.99 at Walmart for 60 vegetarian capsules.
Is it FDA approved?
No. It is a dietary supplement, so it does not require FDA approval before marketing and its claims have not been evaluated by the FDA.