Calocurb is an Amarasate hops extract supplement priced at $89.99 a month, with four published clinical studies behind it and a published average result of 8.3lb over six months.
Overview
Calocurb is built around Amarasate, a New Zealand hops extract. The proposed mechanism is genuinely interesting: bitter compounds delivered to the small intestine trigger the release of gut hormones including GLP-1, reducing appetite. That is a different route from berberine, which acts on the AMPK enzyme, and different again from probiotics aiming to shift the gut microbiome.
It is the only product in this category we have reviewed with a substantial published trial record. Its science page cites four studies: Obesity Pillars 2026 for weight and body composition, the American Journal of Clinical Nutrition 2022 reporting an 18 percent reduction in calories consumed, Nutrients 2019 reporting a 30 percent reduction in hunger during a 24-hour fast, and Obesity Pillars 2024 reporting a 40 percent reduction in cravings in women during acute fasting.
It also publishes the number that matters, in a footnote rather than a headline: typical results are an average weight loss of 8.3lb versus 0.88lb on placebo after six months of consistent use, alongside a healthy diet and exercise. That is what its 9x more weight loss than willpower alone claim actually rests on, and knowing the underlying figures changes how that headline reads.
Calocurb at a Glance
| Detail | What Calocurb Publishes |
|---|---|
| Type of product | Dietary supplement, prescription-free appetite capsule |
| Active ingredient | Amarasate, a New Zealand hops extract |
| Proposed mechanism | Bitter compounds triggering gut hormone release including GLP-1 |
| Price | $89.99 a month one-time, around $76 on subscription |
| Quantity | 90 capsules per bottle, 45 servings |
| Published trials | Obesity Pillars 2026 and 2024, AJCN 2022, Nutrients 2019 |
| Published weight result | 8.3lb average over 6 months vs 0.88lb placebo |
| Calorie reduction | 18 percent reported in AJCN 2022 |
| Prescription | Not required |
| FDA status | Dietary supplement; claims not evaluated by the FDA |
| Practitioner version | Calocurb CLINICAL, sold through practitioners |
Medications Offered
- None. Calocurb is a dietary supplement, not a medication
- Amarasate hops extract is the active ingredient
- Taken as capsules before meals rather than on a fixed schedule
- No prescription or clinical consultation is required
- Marketed for use alongside a healthy diet and exercise
- A practitioner-exclusive version, Calocurb CLINICAL, is sold separately
Brand-Name or Compounded?
Not applicable in the prescription sense. Calocurb is a dietary supplement, which means no FDA approval is required before marketing and its claims are not evaluated by the FDA. That is not a criticism specific to Calocurb, it is how the category is regulated, but it is why published trials matter more here than marketing language.
Consultation Process
Buy direct or through a retailer
Available from Calocurb, Amazon and practitioner channels, with international shipping.
Take before meals
Calocurb publishes a how-to-take guide; the format is a pre-meal appetite management capsule rather than a daily fixed dose.
Combine with diet and exercise
Its published results are explicitly for use alongside a healthy diet and exercise, not in isolation.
Assess over months, not weeks
Its headline result is measured at six months of consistent use.
Eligibility
- Adults wanting appetite support without a prescription
- No clinical assessment or eligibility screening is involved
- Marketed as suitable alongside diet and exercise
- Check with your clinician if you take other medication
- Not a substitute for prescribed treatment of obesity
- Not evaluated for use during pregnancy or breastfeeding
Provider Involvement and Lab Requirements
Provider Involvement
None in the direct-to-consumer route: this is a retail supplement bought without consultation. A practitioner-exclusive version, Calocurb CLINICAL, is distributed through clinicians. If you are taking a GLP-1 medication or anything else, tell your prescriber before adding an appetite-affecting supplement.
Lab Requirements
Not required and not offered. Calocurb publishes a weight health calculator and a hunger type quiz, which are marketing tools rather than clinical assessments.
Pharmacy Fulfillment and Shipping
Pharmacy Fulfillment
Not applicable. Calocurb is a retail dietary supplement sold through its own site, Amazon and practitioner channels rather than dispensed against a prescription.
Shipping Frequency
Sold internationally with a country selector covering the US, UK, Canada, Australia, New Zealand and much of Europe. Also available on Amazon with subscribe-and-save pricing.
Support Services
- A published science page citing four peer-reviewed studies
- A how-to-take guide and hunger type quiz
- Published customer reviews and a help centre
- Subscription pricing that reduces the monthly cost
- A practitioner channel for clinician-supervised use
- No clinical support, monitoring or personalisation
Pricing
Calocurb is among the most expensive supplements in this category, which is worth weighing against the size of its published effect.
| Plan or Medication | Published Price | What It Covers |
|---|---|---|
| One-month supply, one-time | $89.99 | 90 capsules, 45 servings |
| Subscription | Around $76 a month | Roughly 15 percent saving, per published retail listings |
| Cost per capsule | Around $0.85 | Based on Amazon subscribe-and-save pricing |
| Annual cost | Roughly $900 to $1,080 | Depending on subscription status |
| Prescription cost | None | No consultation or prescription required |
| Calocurb CLINICAL | Sold through practitioners | A separate practitioner-exclusive line |
Pricing reflects what Calocurb published at the time of review and can change without notice. Confirm current pricing directly with the provider before enrolling.
Membership Fees
None. This is a retail product purchase, with a subscription option that reduces the per-month price rather than granting access to anything.
Medication Fees
Not applicable. Calocurb supplies no medication. Note the comparison though: at roughly $900 to $1,080 a year, it costs more than several compounded GLP-1 programmes that produce substantially larger published weight loss.
Cancellation and Refund Policy
Cancellation
A subscription can be cancelled through your account. Because the product is a retail purchase rather than a treatment programme, stopping carries no clinical consequence.
Refunds
Standard consumer retail terms apply and vary by where you buy. Calocurb operates a help centre and contact route; Amazon purchases follow Amazon's return policy.
Insurance, HSA and FSA
Insurance
Not applicable. Over-the-counter dietary supplements are not covered by health insurance.
HSA / FSA
Generally not eligible. Supplements are typically excluded from HSA and FSA reimbursement unless prescribed for a specific diagnosed condition with a Letter of Medical Necessity. Do not assume it qualifies.
For a fuller explanation of how these accounts work with GLP-1 care, see our GLP-1 insurance, HSA and FSA guide.
Who Calocurb May Be Best For
- You want the supplement in this category with the most published evidence
- You cannot take or do not want prescription GLP-1 medication
- You want appetite support alongside diet and exercise, with realistic expectations
- You are willing to spend around $900 a year on a modest effect
- You want a mechanism that is at least biologically plausible
- You have discussed it with your clinician
- The published effect is a fraction of what medications deliver
- $89.99 a month exceeds several compounded GLP-1 programmes
- Trial methodology and sample sizes are not published on the site
- Some trials were in healthy-weight men or acute fasting conditions
- The 9x framing rests on a placebo group that lost almost nothing
- Not FDA evaluated, like all dietary supplements
Alternatives to Consider
Supergut GLP-1 Daily Support
Cheaper prebiotic fibre with a larger randomised trial behind it.
SoWell GLP-1 Support System
If you are already on medication and want repletion rather than a substitute.
Kroger Pharmacy
The oral GLP-1 at around $149 a month, an FDA-approved product for not much more.
Cora Health
Compounded semaglutide from $99 a month, if a prescription is an option for you.
You can also compare the whole field in our GLP-1 provider comparison and best online GLP-1 providers roundups.
Frequently Asked Questions
Does Calocurb actually work?
It has the most published evidence of any product in this category, and its own trials report an average 8.3lb weight loss over six months versus 0.88lb on placebo. That is a real effect. It is also roughly 4 percent of body weight for a 200lb person, against around 15 percent in semaglutide trials and 21 percent in tirzepatide trials.
How much does Calocurb cost?
$89.99 for a one-month supply of 90 capsules (45 servings) bought outright, or around $76 a month on subscription. That is roughly $900 to $1,080 a year.
What is Amarasate?
A New Zealand hops extract. The proposed mechanism is that bitter compounds delivered to the small intestine trigger the release of gut hormones including GLP-1, reducing appetite and food intake.
What studies support Calocurb?
Its science page cites four: Obesity Pillars 2026 on weight and body composition, the American Journal of Clinical Nutrition 2022 reporting an 18 percent calorie reduction, Nutrients 2019 reporting 30 percent reduced hunger during a 24-hour fast, and Obesity Pillars 2024 on cravings during acute fasting.
Is Calocurb the same as a GLP-1 medication?
No. It is a dietary supplement that may modestly increase your own GLP-1 release. Prescription GLP-1 agonists are modified molecules resistant to breakdown, producing blood concentrations orders of magnitude above natural levels. The two are not comparable in effect size.
Can I take Calocurb with a GLP-1 medication?
Ask your prescriber first. Combining an appetite-suppressing supplement with an appetite-suppressing medication is not something to do without telling the clinician managing your treatment.
Is Calocurb FDA approved?
No. It is a dietary supplement, which does not require FDA approval before marketing, and its claims have not been evaluated by the FDA.
Medical Disclaimer
This review is for general information only and is not medical advice, a diagnosis, or a treatment recommendation. GLP-1 medications are prescription drugs with real risks and contraindications. Only a licensed clinician who knows your history can decide whether any medication is appropriate for you. Never start, stop, or change a prescription based on this page. If you have a medical emergency, call 911.
Details on this page describe what Calocurb published at the time of review. Programs, pricing, pharmacy partners, and policies change; verify everything directly with the provider before enrolling. See our full medical disclaimer.
Date reviewed: August 30, 2026